Cycloprodigiosin hydrocloride suppresses tumor necrosis factor (TNF) alpha-induced transcriptional activation by NF-kappaB.

Kamata, K; Okamoto, S; Oka, S; Kamata, H; Yagisawa, H; Hirata, H

Kamata, K; Okamoto, S; Oka, S; Kamata, H; Yagisawa, H; Hirata, H.

Affiliation

Kamata K; Department of Life Science, Faculty of Science, Himeji Institute of Technology, kamigori-chou, Akoh-gun, 678-1297, Hyogo, Japan.

FEBS Lett ; 507(1): 74-80, 2001 Oct 19.

Article in En | MEDLINE | ID: mdl-11682062

Subject(s)

Indoles/pharmacology; MAP Kinase Kinase Kinase 1; NF-kappa B/metabolism; Pyrroles/pharmacology; Transcriptional Activation/drug effects; Tumor Necrosis Factor-alpha/antagonists & inhibitors; Apoptosis/drug effects; Base Sequence; Genes, Reporter; HeLa Cells; Humans; I-kappa B Kinase; Indoles/administration & dosage; Luciferases/genetics; Plasmids/genetics; Protein Serine-Threonine Kinases/genetics; Pyrroles/administration & dosage; Signal Transduction; Tetradecanoylphorbol Acetate/pharmacology; Tumor Necrosis Factor-alpha/administration & dosage; cdc42 GTP-Binding Protein/genetics; rac1 GTP-Binding Protein/genetics

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Database: MEDLINE Main subject: Pyrroles / Transcriptional Activation / NF-kappa B / Tumor Necrosis Factor-alpha / MAP Kinase Kinase Kinase 1 / Indoles Limits: Humans Language: En Year: 2001 Type: Article

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