Cytoplasm/enzymology; DNA-Binding Proteins/metabolism; Neoplasm Proteins; Peroxidases/metabolism; Saccharomyces cerevisiae Proteins; Transcription Factors/metabolism; Antioxidants/pharmacology; Base Sequence; Blotting, Northern; Blotting, Western; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases/metabolism; Dose-Response Relationship, Drug; Down-Regulation; Gene Deletion; Genetic Vectors; Hot Temperature; Molecular Sequence Data; Mutation; Oxidative Stress; Peroxiredoxins; Promoter Regions, Genetic; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; Saccharomyces cerevisiae/enzymology; Saccharomyces cerevisiae/metabolism; Signal Transduction; Sirolimus/pharmacology; Temperature; Time Factors; Transcription, Genetic; Transcriptional Activation; beta-Galactosidase/metabolism