Determination of nelfinavir free drug concentrations in plasma by equilibrium dialysis and liquid chromatography/tandem mass spectrometry: important factors for method optimization.

Herforth, Claudia; Stone, Judith A; Jayewardene, Anura L; Blaschke, Terrence F; Fang, Fang; Motoya, Toshiro; Aweeka, Francesca T

Herforth, Claudia; Stone, Judith A; Jayewardene, Anura L; Blaschke, Terrence F; Fang, Fang; Motoya, Toshiro; Aweeka, Francesca T.

Affiliation

Herforth C; Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, CA 94143-0622, USA.

Eur J Pharm Sci ; 15(2): 185-95, 2002 Mar.

Article in En | MEDLINE | ID: mdl-11849916

Subject(s)

Chromatography, Liquid/methods; Dialysis/methods; HIV Protease Inhibitors/blood; Mass Spectrometry/methods; Nelfinavir/blood; Adsorption; Calibration; Chemical Phenomena; Chemistry, Physical; Humans; Hydrogen-Ion Concentration; Molecular Structure; Protein Binding; Reproducibility of Results; Sensitivity and Specificity

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Database: MEDLINE Main subject: Mass Spectrometry / Chromatography, Liquid / HIV Protease Inhibitors / Nelfinavir / Dialysis Type of study: Diagnostic_studies Limits: Humans Language: En Year: 2002 Type: Article

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