Simvastatin improves endothelial function in spontaneously hypertensive rats through a superoxide dismutase mediated antioxidant effect.

Carneado, Joaquin; Alvarez de Sotomayor, Maria; Perez-Guerrero, Concepción; Jimenez, Luis; Herrera, Maria D; Pamies, Encarnación; Martin-Sanz, Maria D V; Stiefel, Pablo; Miranda, Maria; Bravo, Luis; Marhuenda, Elisa

Carneado, Joaquin; Alvarez de Sotomayor, Maria; Perez-Guerrero, Concepción; Jimenez, Luis; Herrera, Maria D; Pamies, Encarnación; Martin-Sanz, Maria D V; Stiefel, Pablo; Miranda, Maria; Bravo, Luis; Marhuenda, Elisa.

Affiliation

Carneado J; Hypertension and Lipids Unit, Department of Internal Medicine, Virgen del Rocío University Hospital, Seville, Spain. jcarneado@hvr.sas.cica.es

J Hypertens ; 20(3): 429-37, 2002 Mar.

Article in En | MEDLINE | ID: mdl-11875310

Subject(s)

Antioxidants/pharmacology; Endothelium, Vascular/drug effects; Endothelium, Vascular/physiopathology; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology; Hypertension/physiopathology; Rats, Inbred SHR/physiology; Simvastatin/pharmacology; Superoxide Dismutase/physiology; Animals; Aorta/drug effects; Aorta/physiopathology; Glutathione Peroxidase/metabolism; In Vitro Techniques; Male; Rats; Rats, Inbred WKY; Superoxides/metabolism

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Database: MEDLINE Main subject: Rats, Inbred SHR / Superoxide Dismutase / Endothelium, Vascular / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Simvastatin / Hypertension / Antioxidants Limits: Animals Language: En Year: 2002 Type: Article

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