Toll-like receptor 2 and 4 (TLR2 and TLR4) agonists differentially regulate secretory interleukin-1 receptor antagonist gene expression in macrophages.

Carl, Virginia S; Brown-Steinke, Kathleen; Nicklin, Martin J H; Smith, Michael F

Carl, Virginia S; Brown-Steinke, Kathleen; Nicklin, Martin J H; Smith, Michael F.

Affiliation

Carl VS; Digestive Health Center of Excellence and Department of Microbiology, University of Virginia Health System, Charlottesville, Virginia 22908, USA.

J Biol Chem ; 277(20): 17448-56, 2002 May 17.

Article in En | MEDLINE | ID: mdl-11877429

Subject(s)

Drosophila Proteins; Macrophages/metabolism; Membrane Glycoproteins/agonists; Receptors, Cell Surface/agonists; Sialoglycoproteins/genetics; Animals; Cell Line; Enzyme Activation; Gene Expression Regulation; Humans; Interleukin 1 Receptor Antagonist Protein; Lipopolysaccharides/pharmacology; Macrophages/drug effects; Mice; Mitogen-Activated Protein Kinases/metabolism; Peptidoglycan/pharmacology; Promoter Regions, Genetic; Proto-Oncogene Proteins/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Toll-Like Receptor 2; Toll-Like Receptor 4; Toll-Like Receptors; Trans-Activators/metabolism; Transfection; p38 Mitogen-Activated Protein Kinases

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Database: MEDLINE Main subject: Sialoglycoproteins / Membrane Glycoproteins / Receptors, Cell Surface / Drosophila Proteins / Macrophages Limits: Animals / Humans Language: En Year: 2002 Type: Article

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