[Congenital megalocornea]. / La mégalocornée congénitale.
J Fr Ophtalmol
; 25(3): 312-8, 2002 Mar.
Article
in Fr
| MEDLINE
| ID: mdl-11941259
ABSTRACT
Congenital megalocornea is a bilateral enlargement of the cornea's diameter that can be associated with trabecula and/or iris dysgenesis. This condition predisposes the patient to glaucoma. The physiopathology is poorly understood and may be related to lens induction during embryological development of the anterior of the eye. X-linked genetic transmission is found in 50% of cases, autosomal transmission in 40%, and sporadic transmission in the remaining 10%. Diagnosis is based on a thorough examination of the child's eye, often with general anesthesia. Different clinical aspects can be observed simple megalocornea without ocular or systemic anomalies, megalocornea with ocular and/or systemic anomalies as well as multiple malformation syndromes, dermatological diseases, skeletal diseases, and genetic or chromosomic diseases. A systematic general pediatric examination is therefore necessary. Congenital megalocornea must be considered, first of all, as a differential diagnosis of primary congenital glaucoma and all of its etiologies. Treatment of associated ocular diseases, the search for an association with systemic diseases, and follow-up for the rest of the patient's life are indispensable.
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Database:
MEDLINE
Main subject:
Eye Diseases, Hereditary
/
Eye Abnormalities
/
Glaucoma
/
Cornea
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Child, preschool
/
Humans
/
Infant
/
Newborn
Language:
Fr
Year:
2002
Type:
Article