Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development.

Bol, David K; Rowley, R Bruce; Ho, Ching-Ping; Pilz, Brigette; Dell, Janet; Swerdel, Mavis; Kiguchi, Kaoru; Muga, Stephanie; Klein, Russell; Fischer, Susan M

Bol, David K; Rowley, R Bruce; Ho, Ching-Ping; Pilz, Brigette; Dell, Janet; Swerdel, Mavis; Kiguchi, Kaoru; Muga, Stephanie; Klein, Russell; Fischer, Susan M.

Affiliation

Bol DK; Bristol-Myers Squibb Pharmaceutical Research Institute, Department of Oncology Drug Discovery, Princeton, New Jersey 08543, USA.

Cancer Res ; 62(9): 2516-21, 2002 May 01.

Article in En | MEDLINE | ID: mdl-11980643

Subject(s)

Isoenzymes/biosynthesis; Prostaglandin-Endoperoxide Synthases/biosynthesis; Skin Neoplasms/enzymology; Skin Neoplasms/prevention & control; Skin/enzymology; 9,10-Dimethyl-1,2-benzanthracene; Alopecia/drug therapy; Alopecia/enzymology; Animals; Carcinogens; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors/pharmacology; Dinoprostone/metabolism; Female; Hair Follicle/drug effects; Humans; Isoenzymes/antagonists & inhibitors; Isoenzymes/genetics; Male; Membrane Proteins; Mice; Mice, Inbred ICR; Mice, Transgenic; Phenotype; Prostaglandin-Endoperoxide Synthases/genetics; Pyrazoles; Skin/drug effects; Skin/metabolism; Skin Neoplasms/chemically induced; Sulfonamides/pharmacology; Tetradecanoylphorbol Acetate

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Database: MEDLINE Main subject: Skin / Skin Neoplasms / Prostaglandin-Endoperoxide Synthases / Isoenzymes Limits: Animals / Female / Humans / Male Language: En Year: 2002 Type: Article

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