Stachyflin and acetylstachyflin, novel anti-influenza A virus substances, produced by Stachybotrys sp. RF-7260. I. Isolation, structure elucidation and biological activities.
J Antibiot (Tokyo)
; 55(2): 155-64, 2002 Feb.
Article
in En
| MEDLINE
| ID: mdl-12002997
ABSTRACT
Two novel compounds, stachyflin and acetylstachyflin, have been isolated by solid-state fermentation of Stachybotrys sp. RF-7260. The structures of both metabolites, determined by detailed NMR analyses and X-ray crystallographic analysis, are novel with a pentacyclic moiety including cis-fused decalin. The absolute stereochemistry of stachyflins was determined by circular dichroism analysis. Stachyflin showed antiviral activity against influenza A virus (H1N1) in vitro with an IC50 value of 0.003 microM. Acetylstachyflin was about 77-fold less active than stachyflin.
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Database:
MEDLINE
Main subject:
Antiviral Agents
/
Sesquiterpenes
/
Heterocyclic Compounds, 4 or More Rings
/
Indoles
Language:
En
Year:
2002
Type:
Article