Alpha(4)beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flow.

Egger, Linda A; Kidambi, Usha; Cao, Jin; Van Riper, Gail; McCauley, Ermengilda; Mumford, Richard A; Amo, Suzanne; Lingham, Russell; Lanza, Thomas; Lin, Linus S; De Laszlo, Stephen E; Young, David N; Kopka, Ihor E; Tong, Sharon; Pikounis, Bill; Benson, Evelyn; Warwood, Sarah; Bargatze, Robert F; Hagmann, William K; Schmidt, John A; Detmers, Patricia A

Egger, Linda A; Kidambi, Usha; Cao, Jin; Van Riper, Gail; McCauley, Ermengilda; Mumford, Richard A; Amo, Suzanne; Lingham, Russell; Lanza, Thomas; Lin, Linus S; De Laszlo, Stephen E; Young, David N; Kopka, Ihor E; Tong, Sharon; Pikounis, Bill; Benson, Evelyn; Warwood, Sarah; Bargatze, Robert F; Hagmann, William K; Schmidt, John A; Detmers, Patricia A.

Affiliation

Egger LA; Pharmacology Division, Merck, PO Box 2000, RY8ON-A26, Rahway, NJ 07065, USA. linda_egger@merck.com

J Pharmacol Exp Ther ; 302(1): 153-62, 2002 Jul.

Article in En | MEDLINE | ID: mdl-12065712

Subject(s)

Integrins/antagonists & inhibitors; Phenylalanine/pharmacology; Receptors, Lymphocyte Homing/antagonists & inhibitors; Animals; Antibodies, Blocking/pharmacology; Antibodies, Monoclonal/pharmacology; Antineoplastic Combined Chemotherapy Protocols/immunology; Cell Adhesion/drug effects; Cell Adhesion Molecules; Cyclophosphamide/immunology; Doxorubicin/immunology; Endothelium, Vascular/cytology; Endothelium, Vascular/drug effects; Etoposide/immunology; Female; Flow Cytometry; Humans; Immunoglobulin G/isolation & purification; Immunoglobulin G/pharmacology; Immunoglobulins; Integrin alpha4beta1; Ligands; Lymphocytes/drug effects; Methotrexate/immunology; Mice; Mice, Inbred BALB C; Mucoproteins/antagonists & inhibitors; Peyer's Patches/cytology; Peyer's Patches/drug effects; Phenylalanine/analogs & derivatives; Recombinant Fusion Proteins/pharmacology; Rheology

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Database: MEDLINE Main subject: Phenylalanine / Integrins / Receptors, Lymphocyte Homing Limits: Animals / Female / Humans Language: En Year: 2002 Type: Article

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PubMed Links

Database: MEDLINE Main subject: Phenylalanine / Integrins / Receptors, Lymphocyte Homing Limits: Animals / Female / Humans Language: En Year: 2002 Type: Article