Glycated collagen I induces premature senescence-like phenotypic changes in endothelial cells.

Chen, Jun; Brodsky, Sergey V; Goligorsky, David M; Hampel, Dierk J; Li, Hong; Gross, Steven S; Goligorsky, Michael S

Chen, Jun; Brodsky, Sergey V; Goligorsky, David M; Hampel, Dierk J; Li, Hong; Gross, Steven S; Goligorsky, Michael S.

Affiliation

Chen J; Department of Medicine, State University of New York, Stony Brook, NY, USA.

Circ Res ; 90(12): 1290-8, 2002 Jun 28.

Article in En | MEDLINE | ID: mdl-12089067

Subject(s)

Arginine/analogs & derivatives; Collagen Type I/pharmacology; Endothelium, Vascular/metabolism; Animals; Apoptosis; Arginine/pharmacology; Azoles/pharmacology; Cells, Cultured; Cellular Senescence/drug effects; Collagen Type I/metabolism; Diabetes Mellitus, Experimental/pathology; Endothelium, Vascular/cytology; Endothelium, Vascular/drug effects; Free Radical Scavengers/pharmacology; Glycosylation; Humans; Isoindoles; Kinetics; Metalloporphyrins/pharmacology; Nitric Oxide/biosynthesis; Nitric Oxide Synthase/metabolism; Nitric Oxide Synthase Type III; Organoselenium Compounds/pharmacology; Peroxynitrous Acid/metabolism; Phenotype; Rats; Rats, Zucker; beta-Galactosidase/analysis

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Database: MEDLINE Main subject: Arginine / Endothelium, Vascular / Collagen Type I Limits: Animals / Humans Language: En Year: 2002 Type: Article

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PubMed Links

Database: MEDLINE Main subject: Arginine / Endothelium, Vascular / Collagen Type I Limits: Animals / Humans Language: En Year: 2002 Type: Article