Design and synthesis of C-8 linked pyrrolobenzodiazepine-naphthalimide hybrids as anti-tumour agents.

Kamal, Ahmed; Reddy, B S Narayan; Reddy, G Suresh Kumar; Ramesh, G

Kamal, Ahmed; Reddy, B S Narayan; Reddy, G Suresh Kumar; Ramesh, G.

Affiliation

Kamal A; Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India. ahmedkamal@iict.ap.nic.in

Bioorg Med Chem Lett ; 12(15): 1933-5, 2002 Aug 05.

Article in En | MEDLINE | ID: mdl-12113812

Subject(s)

Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/pharmacology; Benzodiazepines/chemical synthesis; Benzodiazepines/pharmacology; Naphthalenes/chemical synthesis; Naphthalenes/pharmacology; Pyrroles/chemical synthesis; Pyrroles/pharmacology; Antineoplastic Agents/metabolism; Benzodiazepines/metabolism; DNA/metabolism; Drug Design; Drug Screening Assays, Antitumor; Humans; Lethal Dose 50; Naphthalenes/metabolism; Pyrroles/metabolism; Structure-Activity Relationship; Tumor Cells, Cultured

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Database: MEDLINE Main subject: Pyrroles / Benzodiazepines / Naphthalenes / Antineoplastic Agents Limits: Humans Language: En Year: 2002 Type: Article

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PubMed Links

Database: MEDLINE Main subject: Pyrroles / Benzodiazepines / Naphthalenes / Antineoplastic Agents Limits: Humans Language: En Year: 2002 Type: Article