SCH 206272: a potent, orally active tachykinin NK(1), NK(2), and NK(3) receptor antagonist.

Anthes, John C; Chapman, Richard W; Richard, Christian; Eckel, Stephen; Corboz, Michel; Hey, John A; Fernandez, Xiomara; Greenfeder, Scott; McLeod, Robbie; Sehring, Susan; Rizzo, Charles; Crawley, Yvette; Shih, Neng-Yang; Piwinski, John; Reichard, Greg; Ting, Pauline; Carruthers, Nick; Cuss, Francis M; Billah, Motasim; Kreutner, William; Egan, Robert W

Anthes, John C; Chapman, Richard W; Richard, Christian; Eckel, Stephen; Corboz, Michel; Hey, John A; Fernandez, Xiomara; Greenfeder, Scott; McLeod, Robbie; Sehring, Susan; Rizzo, Charles; Crawley, Yvette; Shih, Neng-Yang; Piwinski, John; Reichard, Greg; Ting, Pauline; Carruthers, Nick; Cuss, Francis M; Billah, Motasim; Kreutner, William; Egan, Robert W.

Affiliation

Anthes JC; Department of Allergy, Schering-Plough Research Institute, K15-1-1600, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. john.anthes@spcorp.com

Eur J Pharmacol ; 450(2): 191-202, 2002 Aug 23.

Article in En | MEDLINE | ID: mdl-12206858

Subject(s)

Acetamides/pharmacology; Neurokinin-1 Receptor Antagonists; Piperidines/pharmacology; Receptors, Neurokinin-2/antagonists & inhibitors; Receptors, Neurokinin-3/antagonists & inhibitors; Administration, Oral; Animals; Bronchoconstriction/drug effects; Bronchoconstriction/physiology; CHO Cells; Capillary Permeability; Capsaicin/pharmacology; Cough/chemically induced; Cough/drug therapy; Cricetinae; Dogs; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Ileum/drug effects; Ileum/physiology; In Vitro Techniques; Male; Muscle Contraction/drug effects; Muscle, Smooth/drug effects; Muscle, Smooth/physiology; Pulmonary Artery/drug effects; Pulmonary Artery/physiology; Radioligand Assay; Receptors, Neurokinin-1/metabolism; Receptors, Neurokinin-2/metabolism; Receptors, Neurokinin-3/metabolism; Vas Deferens/drug effects; Vas Deferens/physiology

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Database: MEDLINE Main subject: Piperidines / Receptors, Neurokinin-3 / Receptors, Neurokinin-2 / Neurokinin-1 Receptor Antagonists / Acetamides Limits: Animals / Humans / Male Language: En Year: 2002 Type: Article

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