Overexpression of wild-type breast cancer resistance protein mediates methotrexate resistance.

Volk, Erin L; Farley, Kate M; Wu, Yan; Li, Fei; Robey, Robert W; Schneider, Erasmus

Volk, Erin L; Farley, Kate M; Wu, Yan; Li, Fei; Robey, Robert W; Schneider, Erasmus.

Affiliation

Volk EL; Wadsworth Center, Biggs Laboratories, New York State Department of Health, Albany, New York 12201-0509, USA.

Cancer Res ; 62(17): 5035-40, 2002 Sep 01.

Article in En | MEDLINE | ID: mdl-12208758

Subject(s)

ATP-Binding Cassette Transporters/biosynthesis; Antimetabolites, Antineoplastic/pharmacology; Breast Neoplasms/drug therapy; Breast Neoplasms/metabolism; Methotrexate/pharmacology; Neoplasm Proteins; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters/antagonists & inhibitors; ATP-Binding Cassette Transporters/genetics; Breast Neoplasms/genetics; Drug Resistance, Neoplasm; Gene Amplification; Humans; Methotrexate/pharmacokinetics; RNA, Messenger/biosynthesis; RNA, Messenger/genetics; Substrate Specificity; Tumor Cells, Cultured

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Database: MEDLINE Main subject: Breast Neoplasms / Methotrexate / ATP-Binding Cassette Transporters / Neoplasm Proteins / Antimetabolites, Antineoplastic Limits: Humans Language: En Year: 2002 Type: Article

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