Nogo-A expressed in Schwann cells impairs axonal regeneration after peripheral nerve injury.
J Cell Biol
; 159(1): 29-35, 2002 Oct 14.
Article
in En
| MEDLINE
| ID: mdl-12379801
ABSTRACT
Injured axons in mammalian peripheral nerves often regenerate successfully over long distances, in contrast to axons in the brain and spinal cord (CNS). Neurite growth-inhibitory proteins, including the recently cloned membrane protein Nogo-A, are enriched in the CNS, in particular in myelin. Nogo-A is not detectable in peripheral nerve myelin. Using regulated transgenic expression of Nogo-A in peripheral nerve Schwann cells, we show that axonal regeneration and functional recovery are impaired after a sciatic nerve crush. Nogo-A thus overrides the growth-permissive and -promoting effects of the lesioned peripheral nerve, demonstrating its in vivo potency as an inhibitor of axonal regeneration.
Full text:
1
Database:
MEDLINE
Main subject:
Schwann Cells
/
Sciatic Nerve
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Axons
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Growth Inhibitors
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Myelin Proteins
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Nerve Regeneration
Limits:
Animals
/
Humans
Language:
En
Year:
2002
Type:
Article