Human myeloma cells stimulate the receptor activator of nuclear factor-kappa B ligand (RANKL) in T lymphocytes: a potential role in multiple myeloma bone disease.

Giuliani, Nicola; Colla, Simona; Sala, Roberto; Moroni, Matteo; Lazzaretti, Mirca; La Monica, Silvia; Bonomini, Sabrina; Hojden, Magda; Sammarelli, Gabriella; Barillè, Sophie; Bataille, Regis; Rizzoli, Vittorio

Giuliani, Nicola; Colla, Simona; Sala, Roberto; Moroni, Matteo; Lazzaretti, Mirca; La Monica, Silvia; Bonomini, Sabrina; Hojden, Magda; Sammarelli, Gabriella; Barillè, Sophie; Bataille, Regis; Rizzoli, Vittorio.

Affiliation

Giuliani N; Hematology Department of Internal Medicine and Biomedical Science, University of Parma, Parma, Italy. nicola.giuliani@unipr.it

Blood ; 100(13): 4615-21, 2002 Dec 15.

Article in En | MEDLINE | ID: mdl-12393684

Subject(s)

Carrier Proteins/physiology; Membrane Glycoproteins/physiology; Multiple Myeloma/metabolism; Neoplasm Proteins/physiology; Osteolysis/etiology; T-Lymphocytes/physiology; Aged; Bone Marrow Cells/metabolism; Coculture Techniques; Culture Media, Conditioned/pharmacology; Female; Gene Expression Regulation, Neoplastic; Glycoproteins/pharmacology; Humans; Interleukin-6/pharmacology; Interleukin-7/biosynthesis; Interleukin-7/genetics; Interleukin-7/metabolism; Lymphocyte Activation; Male; Middle Aged; Multiple Myeloma/complications; Multiple Myeloma/pathology; Osteoclasts/cytology; Osteoprotegerin; RANK Ligand; RNA, Messenger/biosynthesis; RNA, Neoplasm/biosynthesis; Receptor Activator of Nuclear Factor-kappa B; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; Recombinant Proteins/pharmacology; Stromal Cells/cytology

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Database: MEDLINE Main subject: Osteolysis / Membrane Glycoproteins / T-Lymphocytes / Carrier Proteins / Multiple Myeloma / Neoplasm Proteins Limits: Aged / Female / Humans / Male / Middle aged Language: En Year: 2002 Type: Article

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