Survival of Mycobacterium tuberculosis in host macrophages involves resistance to apoptosis dependent upon induction of antiapoptotic Bcl-2 family member Mcl-1.

Sly, Laura M; Hingley-Wilson, Suzanne M; Reiner, Neil E; McMaster, W Robert

Sly, Laura M; Hingley-Wilson, Suzanne M; Reiner, Neil E; McMaster, W Robert.

Affiliation

Sly LM; Immunity and Infection Research Center, Vancouver Hospital and Health Sciences Center, University of British Columbia, Vancouver, British Columbia, Canada.

J Immunol ; 170(1): 430-7, 2003 Jan 01.

Article in En | MEDLINE | ID: mdl-12496428

Subject(s)

Apoptosis/immunology; Macrophages/cytology; Macrophages/microbiology; Mycobacterium tuberculosis/growth & development; Mycobacterium tuberculosis/immunology; Neoplasm Proteins/biosynthesis; Proto-Oncogene Proteins c-bcl-2/biosynthesis; Apoptosis/drug effects; Cells, Cultured; Humans; Immunity, Innate; Intracellular Fluid/metabolism; Intracellular Fluid/microbiology; Macrophages/drug effects; Macrophages/immunology; Mycobacterium tuberculosis/pathogenicity; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins/antagonists & inhibitors; Neoplasm Proteins/genetics; Neoplasm Proteins/physiology; Oligonucleotides, Antisense/pharmacology; Proto-Oncogene Proteins c-bcl-2/genetics; Proto-Oncogene Proteins c-bcl-2/physiology; RNA, Messenger/biosynthesis; Tumor Cells, Cultured/immunology; Tumor Cells, Cultured/microbiology; Up-Regulation/drug effects; Up-Regulation/immunology; Virulence

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Database: MEDLINE Main subject: Apoptosis / Proto-Oncogene Proteins c-bcl-2 / Macrophages / Mycobacterium tuberculosis / Neoplasm Proteins Limits: Humans Language: En Year: 2003 Type: Article

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