Rapid in vivo screening of experimental drugs for tuberculosis using gamma interferon gene-disrupted mice.
Antimicrob Agents Chemother
; 47(2): 783-5, 2003 Feb.
Article
in En
| MEDLINE
| ID: mdl-12543692
ABSTRACT
We have developed a rapid new in vivo method for screening experimental drugs for their activity against Mycobacterium tuberculosis by using the gamma interferon gene-disrupted (GKO) C57BL/6 mouse. Due to the rapid growth of the infection, statistical differences indicating positive efficacy of active compounds can be seen after only 8 days of treatment. To validate this model, several fluoroquinolones, including ciprofloxacin, levofloxacin, moxifloxacin, and gatifloxacin, were tested in parallel.
Full text:
1
Database:
MEDLINE
Main subject:
Tuberculosis
/
Anti-Infective Agents
Type of study:
Diagnostic_studies
/
Screening_studies
Limits:
Animals
Language:
En
Year:
2003
Type:
Article