Dimethylsilane polyamines: cytostatic compounds with potentials as anticancer drugs. II. Uptake and potential cytotoxic mechanisms.

Le Roch, N; Douaud, F; Havouis, R; Delcros, J G; Vaultier, M; Moulinoux, J P; Seiler, N

Le Roch, N; Douaud, F; Havouis, R; Delcros, J G; Vaultier, M; Moulinoux, J P; Seiler, N.

Affiliation

Le Roch N; Synthèse et Electrosynthèse Organique, Institut de Chimie, Université de Rennes 1, Rennes, France.

Anticancer Res ; 22(6B): 3765-76, 2002.

Article in En | MEDLINE | ID: mdl-12552990

Subject(s)

Antineoplastic Agents/pharmacology; Antineoplastic Agents/pharmacokinetics; Calmodulin/analogs & derivatives; Polyamines/pharmacology; Polyamines/pharmacokinetics; Silanes/pharmacology; Silanes/pharmacokinetics; Animals; CHO Cells/drug effects; CHO Cells/metabolism; Calmodulin/metabolism; Cell Aggregation/drug effects; Cell Cycle/drug effects; Cell Division/drug effects; Cricetinae; DNA, Neoplasm/metabolism; Drug Screening Assays, Antitumor; Leucine/antagonists & inhibitors; Leucine/metabolism; Leukemia L1210/drug therapy; Leukemia L1210/metabolism; Methenamine/pharmacokinetics; Methenamine/pharmacology; Mice; Microsomes, Liver/drug effects; Oxidoreductases Acting on CH-NH Group Donors/antagonists & inhibitors; Oxidoreductases Acting on CH-NH Group Donors/metabolism; Rats; Spermidine/antagonists & inhibitors; Spermidine/pharmacokinetics; Thymidine/antagonists & inhibitors; Thymidine/metabolism; Polyamine Oxidase

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Database: MEDLINE Main subject: Polyamines / Silanes / Calmodulin / Antineoplastic Agents Limits: Animals Language: En Year: 2002 Type: Article

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PubMed Links

Database: MEDLINE Main subject: Polyamines / Silanes / Calmodulin / Antineoplastic Agents Limits: Animals Language: En Year: 2002 Type: Article