Contraceptive agents from cycloaddition reactions of diarylcyclopropenones and diarylthiirene 1, 1-dioxides.
J Med Chem
; 19(3): 414-9, 1976 Mar.
Article
in En
| MEDLINE
| ID: mdl-1255666
ABSTRACT
PIP: The antifertility activity from the reactions of diphenylcyclopropene (1) and 2,3-diphenylthiirene 1,1 dioxide (2) with enamines was investigated in laboratory rodents. A considerable dissociation of antifertility from estrogenic activity was observed in certain instances. Stilbene amides (7) and stilbene aminoketones (8) we re extensively studied. The stilbene aminoketone group provided several materials of which compound 21 was found to be a highly potent antifertility agent. The preparation of the materials is described.
Key words
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Database:
MEDLINE
Main subject:
Bridged Bicyclo Compounds
/
Bridged-Ring Compounds
/
Contraceptives, Oral, Synthetic
/
Cyclopropanes
Limits:
Animals
/
Pregnancy
Language:
En
Year:
1976
Type:
Article