Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease.

Holbert, Sébastien; Dedeoglu, Alpaslan; Humbert, Sandrine; Saudou, Frédéric; Ferrante, Robert J; Néri, Christian

Holbert, Sébastien; Dedeoglu, Alpaslan; Humbert, Sandrine; Saudou, Frédéric; Ferrante, Robert J; Néri, Christian.

Affiliation

Holbert S; Laboratory of Genomic Biology, Institut National de la Santé et de la Recherche Médicale-Avenir Group and Fondation Jean Dausset-Centre d'Etude du Polymorphisme Humain, 75010 Paris, France.

Proc Natl Acad Sci U S A ; 100(5): 2712-7, 2003 Mar 04.

Article in En | MEDLINE | ID: mdl-12604778

Subject(s)

Huntington Disease/genetics; Huntington Disease/pathology; Microtubule-Associated Proteins/metabolism; Microtubule-Associated Proteins/physiology; Nerve Tissue Proteins/chemistry; Nuclear Proteins/chemistry; Aged; Animals; Blotting, Western; Brain/cytology; Brain/metabolism; Caenorhabditis elegans/metabolism; Cell Death; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Gene Library; Humans; Huntingtin Protein; Immunohistochemistry; Lymphocytes/metabolism; Middle Aged; Minor Histocompatibility Antigens; Mutation; Nerve Tissue Proteins/metabolism; Neurons/cytology; Neurons/pathology; Nuclear Proteins/metabolism; Peptides/chemistry; Protein Binding; Protein Structure, Tertiary; RNA, Messenger/metabolism; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Two-Hybrid System Techniques; Ubiquitin/metabolism; Up-Regulation; rho GTP-Binding Proteins/metabolism

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Full text: 1 Database: MEDLINE Main subject: Nuclear Proteins / Huntington Disease / Microtubule-Associated Proteins / Nerve Tissue Proteins Type of study: Prognostic_studies Language: En Year: 2003 Type: Article

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