Development and validation of a liquid chromatography-tandem mass spectrometric assay for Eplerenone and its hydrolyzed metabolite in human plasma.

Zhang, Ji Y; Fast, Douglas M; Breau, Alan P

Zhang, Ji Y; Fast, Douglas M; Breau, Alan P.

Affiliation

Zhang JY; Global Drug Metabolism, Pharmacia, 4901 Searle Parkway, Skokie, IL 60077, USA. ji.y.zhang@pharmacia.com

J Chromatogr B Analyt Technol Biomed Life Sci ; 787(2): 333-44, 2003 Apr 25.

Article in En | MEDLINE | ID: mdl-12650756

Subject(s)

Chromatography, High Pressure Liquid/methods; Mass Spectrometry/methods; Spironolactone/analogs & derivatives; Spironolactone/blood; Eplerenone; Hemolysis; Humans; Hydrolysis; Reference Standards; Reproducibility of Results

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Database: MEDLINE Main subject: Mass Spectrometry / Spironolactone / Chromatography, High Pressure Liquid Type of study: Guideline Limits: Humans Language: En Year: 2003 Type: Article

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