Impaired gametogenesis in mice that overexpress the RNA-binding protein HuR.
EMBO Rep
; 4(4): 394-9, 2003 Apr.
Article
in En
| MEDLINE
| ID: mdl-12671683
ABSTRACT
A series of experiments, using cell culture models or in vitro assays, has shown that the RNA-binding protein HuR increases the half-life of some messenger RNAs that contain adenylate/uridylate-rich decay elements. However, its function in an integrated system has not yet been investigated. Here, using a mouse model, we report that misregulation of HuR, due to expression of an HuR transgene, prevents the production of fully functional gametes. This work provides the first evidence for a physiological function of HuR, and highlights its involvement in spermatogenesis.
Full text:
1
Database:
MEDLINE
Main subject:
Gene Expression Regulation
/
RNA-Binding Proteins
/
Gametogenesis
/
Antigens, Surface
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
En
Year:
2003
Type:
Article