[Clinical and experimental studies on five cases of acute myeloid leukemia with translocation t(16;21)(p11;q22)].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
; 20(2): 171-3, 2003 Apr.
Article
in Zh
| MEDLINE
| ID: mdl-12673593
ABSTRACT
OBJECTIVE:
To report five cases of acute myeloid leukemia (AML) with t(16;21)(p11;q22) translocation and the result of chromosome painting analysis on one of them.METHODS:
Chromosome specimens were prepared by short-term culture of bone marrow cells. Karyotype analysis was made by R-banding technique. Chromosome painting was performed using whole chromosome probes 16 and 21 in 1 case.RESULTS:
Karyotype analysis showed identical translocation t(16;21)(p11;q22) in all five cases, accounting for 0.3% of 1448 cases of acute myeoid leukemia examined in the past fifteen years. Moreover, chromosome painting distinctly demonstrated t(16;21) in one of them. Leukemia blasts did not show hemophagocytosis in all of them.CONCLUSION:
t(16;21) translocation is a rare and recurring chromosome rearrangement. It represents a specific type of AML. Chromosome painting technique is a more reliable means for detecting it, compared with the conventional karyotype analysis.
Search on Google
Database:
MEDLINE
Main subject:
Translocation, Genetic
/
Chromosomes, Human, Pair 16
/
Chromosomes, Human, Pair 21
/
Leukemia, Myeloid
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Language:
Zh
Year:
2003
Type:
Article