An indolent B-cell lymphoma with t(2;8)(p12;q24) abnormality and absence of C-MYC amplification and TP53 deletion. A new variant?
Cancer Genet Cytogenet
; 144(1): 76-9, 2003 Jul 01.
Article
in En
| MEDLINE
| ID: mdl-12810261
ABSTRACT
The translocation between chromosomes 2 and 8, t(2;8), is well known for its strong association with high-grade Burkitt lymphoma. However, the significance of this translocation in indolent lymphoproliferative disorders is not clear. We present the case of a 75-year-old white male with left upper quadrant abdominal pain, splenomegaly, and an elevated white cell count of 30.3x10(9) cells/L (84% large lymphoid cells with scanty cytoplasm and prominent central nucleoli). Immunophenotyping revealed a clonal B-cell population coexpressing CD5, CD19, and CD20 with weak CD23 and CD25 and very weak, restricted, surface lambda. The cytogenetic analysis showed all 20 cells with t(2;8)(p12;q24.3). In addition, four of the 20 cells also showed a second translocation t(12;17)(p13;q21). Molecular analysis using c-myc and p53 probes showed normal results with no indication of amplification of C-MYC or deletion of TP53. The patient was managed as an indo-lent/low-grade lymphoproliferative disorder with excellent response to eight cycles of fludarabine.
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Database:
MEDLINE
Main subject:
Translocation, Genetic
/
Chromosomes, Human, Pair 2
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Chromosomes, Human, Pair 8
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Gene Amplification
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Genes, myc
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Genes, p53
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Lymphoma, B-Cell
Limits:
Aged
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Humans
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Male
Language:
En
Year:
2003
Type:
Article