[Congenital malformations and chronic diseases of the mother. Latin American Collaborative Study of Congenital Malformations (ECLAMC) 1971-1999]. / Malformaciones congénitas y patología crónica de la madre. Estudio ECLAMC 1971-1999.
Rev Med Chil
; 131(4): 404-11, 2003 Apr.
Article
in Es
| MEDLINE
| ID: mdl-12870235
ABSTRACT
BACKGROUND:
Several maternal diseases, such as diabetes mellitus or high blood pressure, are associated with a higher risk for fetal or neonatal problems.AIM:
To study the association between chronic diseases of the mother and congenital malformations. MATERIAL ANDMETHODS:
Review of the records of the Latin American Collaborative Study of Congenital Malformations (ECLAMC) at the University of Chile Clinical Hospital. A sample of 383 mothers with a chronic disease was compared with 297 healthy mothers. The presence of congenital malformations in the newborns was studied. The odds ratio (OR) of a mother to have a child with a congenital malformation was calculated.RESULTS:
Mothers with bronchial asthma, diabetes mellitus, hypertension and hypothyroidism had an OR over 1 of having a child with a congenital malformation. No association between maternal obesity and offspring malformations was observed. Offspring of diabetic mothers had 8.95 times more probabilities of having a major malformation and 4.95 times more probabilities of having a minor defect.CONCLUSIONS:
Offspring of mothers with diabetes mellitus, bronchial asthma, hypertension or hypothyroidism have a higher risk of presenting a congenital malformation, when compared with offspring of healthy mothers.
Search on Google
Database:
MEDLINE
Main subject:
Pregnancy Complications
/
Congenital Abnormalities
/
Hospitals, Maternity
Type of study:
Etiology_studies
/
Observational_studies
Limits:
Female
/
Humans
/
Newborn
/
Pregnancy
Country/Region as subject:
America do sul
/
Chile
Language:
Es
Year:
2003
Type:
Article