Neurochemical and behavioural modifications induced by scrapie infection in golden hamsters.
Brain Res
; 984(1-2): 237-41, 2003 Sep 12.
Article
in En
| MEDLINE
| ID: mdl-12932859
ABSTRACT
Scrapie-infected hamsters were tested for spontaneous motor activity and passive avoidance at various times after infection. After testing, some animals were killed and their whole brains assayed for norepinephrine, dopamine, serotonin and their metabolites. The apparent rate of turnover was estimated in terms of metabolite/amine concentrations. After 70 days, there was a decrease in passive avoidance and dopamine and serotonin. Passive avoidance correlated with the apparent rate of turnover of dopamine, whereas motor activity correlated with that of serotonin and dopamine.
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Database:
MEDLINE
Main subject:
Scrapie
/
Avoidance Learning
/
Dopamine
/
Serotonin
/
Motor Activity
Limits:
Animals
Language:
En
Year:
2003
Type:
Article