Design of quinolinedione-based geldanamycin analogues.

Hargreaves, Robert; David, Cynthia L; Whitesell, Luke; Skibo, Edward B

Hargreaves, Robert; David, Cynthia L; Whitesell, Luke; Skibo, Edward B.

Affiliation

Hargreaves R; Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287-1604, USA.

Bioorg Med Chem Lett ; 13(18): 3075-8, 2003 Sep 15.

Article in En | MEDLINE | ID: mdl-12941337

Subject(s)

HSP90 Heat-Shock Proteins/antagonists & inhibitors; Quinolones/chemistry; Quinones/chemical synthesis; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/pharmacology; Benzoquinones; Binding Sites; Cell Line, Tumor; Cell Survival/drug effects; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Lactams, Macrocyclic; Quinolones/pharmacology; Quinones/pharmacology; Structure-Activity Relationship

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PubMed Links

Database: MEDLINE Main subject: Quinones / Quinolones / HSP90 Heat-Shock Proteins Type of study: Prognostic_studies Limits: Humans Language: En Year: 2003 Type: Article

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PubMed Links

Database: MEDLINE Main subject: Quinones / Quinolones / HSP90 Heat-Shock Proteins Type of study: Prognostic_studies Limits: Humans Language: En Year: 2003 Type: Article