Correlation of serum metalloproteinase levels with lung cancer metastasis and response to therapy.
Cancer Res
; 52(16): 4548-9, 1992 Aug 15.
Article
in En
| MEDLINE
| ID: mdl-1322794
ABSTRACT
Cancer cells elaborate metalloproteinases which may play a role in invasion and metastasis. The serum level of the M(r) 72,000 type IV collagenase (MMP-2) was measured in 87 lung cancer patients. Stage IV cancer levels were significantly elevated (P less than 0.0001) compared to normal sera. A significant difference (P less than 0.01) was found between enzyme levels in the presence versus the absence of distant metastasis. For 29 patients treated with combination chemotherapy, a positive relationship was noted between response failure and elevated enzyme levels. Serum metalloproteinase levels may provide information relevant to prognosis as well as treatment decisions.
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Database:
MEDLINE
Main subject:
Biomarkers, Tumor
/
Microbial Collagenase
/
Lung Neoplasms
Limits:
Humans
Language:
En
Year:
1992
Type:
Article