Second hand smoke stimulates tumor angiogenesis and growth.
Cancer Cell
; 4(3): 191-6, 2003 Sep.
Article
in En
| MEDLINE
| ID: mdl-14522253
ABSTRACT
Exposure to second hand smoke (SHS) is believed to cause lung cancer. Pathological angiogenesis is a requisite for tumor growth. Lewis lung cancer cells were injected subcutaneously into mice, which were then exposed to sidestream smoke (SHS) or clean room air and administered vehicle, cerivastatin, or mecamylamine. SHS significantly increased tumor size, weight, capillary density, VEGF and MCP-1 levels, and circulating endothelial progenitor cells (EPC). Cerivastatin (an inhibitor of HMG-coA reductase) or mecamylamine (an inhibitor of nicotinic acetylcholine receptors) suppressed the effect of SHS to increase tumor size and capillary density. Cerivastatin reduced MCP-1 levels, whereas mecamylamine reduced VEGF levels and EPC. These studies reveal that SHS promotes tumor angiogenesis and growth. These effects of SHS are associated with increases in plasma VEGF and MCP-1 levels, and EPC, mediated in part by isoprenylation and nicotinic acetylcholine receptors.
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Database:
MEDLINE
Main subject:
Tobacco Smoke Pollution
/
Carcinoma, Lewis Lung
/
Neovascularization, Pathologic
/
Nicotine
Limits:
Animals
Language:
En
Year:
2003
Type:
Article