Estradiol prevents amyloid-beta peptide-induced cell death in a cholinergic cell line via modulation of a classical estrogen receptor.

Marin, R; Guerra, B; Hernández-Jiménez, J-G; Kang, X-L; Fraser, J D; López, F J; Alonso, R

Marin, R; Guerra, B; Hernández-Jiménez, J-G; Kang, X-L; Fraser, J D; López, F J; Alonso, R.

Affiliation

Marin R; Laboratory of Cellular Neurobiology, Department of Physiology, University of La Laguna, School of Medicine, 38071 Santa Cruz de Tenerife, Spain.

Neuroscience ; 121(4): 917-26, 2003.

Article in En | MEDLINE | ID: mdl-14580942

Subject(s)

Amyloid beta-Peptides/antagonists & inhibitors; Estradiol/metabolism; Neurons/metabolism; Neuroprotective Agents/metabolism; Peptide Fragments/antagonists & inhibitors; Receptors, Estrogen/metabolism; Acetylcholine/metabolism; Alzheimer Disease/metabolism; Amyloid beta-Peptides/toxicity; Animals; Cell Death/drug effects; Cell Death/physiology; Cell Line; Cell Nucleus/drug effects; Cell Nucleus/metabolism; Cytoplasm/drug effects; Cytoplasm/metabolism; Dose-Response Relationship, Drug; Estradiol/pharmacology; Estrogen Antagonists/pharmacology; Estrogen Receptor alpha; Mice; Neurons/drug effects; Neurons/pathology; Neuroprotective Agents/pharmacology; Peptide Fragments/toxicity; Receptors, Estrogen/drug effects; Repressor Proteins/drug effects; Repressor Proteins/genetics; Up-Regulation/drug effects; Up-Regulation/physiology

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Database: MEDLINE Main subject: Peptide Fragments / Receptors, Estrogen / Amyloid beta-Peptides / Neuroprotective Agents / Estradiol / Neurons Limits: Animals Language: En Year: 2003 Type: Article

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