Enfuvirtide: the first therapy to inhibit the entry of HIV-1 into host CD4 lymphocytes.
Nat Rev Drug Discov
; 3(3): 215-25, 2004 Mar.
Article
in En
| MEDLINE
| ID: mdl-15031735
ABSTRACT
Highly active antiretroviral therapy (HAART) based on combinations of drugs that target key enzymes in the life-cycle of human immunodeficiency virus (HIV) has considerably reduced morbidity and mortality from HIV infection since its introduction in the mid-1990s. However, the growing problem of the emergence of HIV strains that are resistant not only to individual drugs, but to whole drug classes, means that agents with new mechanisms of action are needed. Here, we describe the discovery and development of enfuvirtide (Fuzeon), the first drug to inhibit the entry of HIV-1 into host cells.
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Database:
MEDLINE
Main subject:
Peptide Fragments
/
CD4-Positive T-Lymphocytes
/
HIV Envelope Protein gp41
/
Acquired Immunodeficiency Syndrome
/
HIV-1
/
HIV Fusion Inhibitors
Limits:
Animals
/
Humans
Language:
En
Year:
2004
Type:
Article