Discovery of novel 2,8-diazaspiro[4.5]decanes as orally active glycoprotein IIb-IIIa antagonists.

Mehrotra, Mukund M; Heath, Julie A; Smyth, Mark S; Pandey, Anjali; Rose, Jack W; Seroogy, Joseph M; Volkots, Deborah L; Nannizzi-Alaimo, Lisa; Park, Gary L; Lambing, Joseph L; Hollenbach, Stanley J; Scarborough, Robert M

Mehrotra, Mukund M; Heath, Julie A; Smyth, Mark S; Pandey, Anjali; Rose, Jack W; Seroogy, Joseph M; Volkots, Deborah L; Nannizzi-Alaimo, Lisa; Park, Gary L; Lambing, Joseph L; Hollenbach, Stanley J; Scarborough, Robert M.

Affiliation

Mehrotra MM; Millennium Pharmaceuticals Inc., 256 E. Grand Avenue, South San Francisco, CA 94080, USA. mukund_mehotra@hotmail.com

J Med Chem ; 47(8): 2037-61, 2004 Apr 08.

Article in En | MEDLINE | ID: mdl-15056002

Subject(s)

Alkanes/chemical synthesis; Aza Compounds/chemical synthesis; Hydroxylamines/chemical synthesis; Platelet Aggregation Inhibitors/chemical synthesis; Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors; Prodrugs/chemical synthesis; Spiro Compounds/chemical synthesis; Administration, Oral; Alkanes/pharmacokinetics; Alkanes/pharmacology; Animals; Aza Compounds/pharmacokinetics; Aza Compounds/pharmacology; Binding, Competitive; Biological Availability; Bleeding Time; Dogs; Humans; Hydantoins/chemical synthesis; Hydantoins/pharmacokinetics; Hydantoins/pharmacology; Hydroxylamines/pharmacokinetics; Hydroxylamines/pharmacology; In Vitro Techniques; Lactams/chemical synthesis; Lactams/pharmacokinetics; Lactams/pharmacology; Macaca fascicularis; Mice; Platelet Aggregation Inhibitors/pharmacokinetics; Platelet Aggregation Inhibitors/pharmacology; Platelet Glycoprotein GPIIb-IIIa Complex/metabolism; Prodrugs/pharmacokinetics; Prodrugs/pharmacology; Rats; Rats, Sprague-Dawley; Spiro Compounds/pharmacokinetics; Spiro Compounds/pharmacology; Structure-Activity Relationship; Urea/analogs & derivatives; Urea/chemical synthesis; Urea/pharmacokinetics; Urea/pharmacology

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Database: MEDLINE Main subject: Spiro Compounds / Aza Compounds / Platelet Aggregation Inhibitors / Prodrugs / Platelet Glycoprotein GPIIb-IIIa Complex / Alkanes / Hydroxylamines Language: En Year: 2004 Type: Article

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