Cytotoxic alpha-halogenoacrylic derivatives of distamycin A and congeners.

Beria, Italo; Baraldi, Pier Giovanni; Cozzi, Paolo; Caldarelli, Marina; Geroni, Cristina; Marchini, Sergio; Mongelli, Nicola; Romagnoli, Romeo

Beria, Italo; Baraldi, Pier Giovanni; Cozzi, Paolo; Caldarelli, Marina; Geroni, Cristina; Marchini, Sergio; Mongelli, Nicola; Romagnoli, Romeo.

Affiliation

Beria I; Pharmacia Italia S.p.A., Discovery Research Oncology, Viale Pasteur 10, 20014 Nerviano, Milan, Italy. italo.beria@pharmacia.com

J Med Chem ; 47(10): 2611-23, 2004 May 06.

Article in En | MEDLINE | ID: mdl-15115402

Subject(s)

Antineoplastic Agents/chemical synthesis; Distamycins/chemical synthesis; Guanidines/chemical synthesis; Pyrroles/chemical synthesis; Animals; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Cell Line, Tumor; Distamycins/chemistry; Distamycins/pharmacology; Drug Screening Assays, Antitumor; Female; Glutathione/metabolism; Guanidines/chemistry; Guanidines/pharmacology; Humans; Inhibitory Concentration 50; Mice; Mice, Nude; Neoplasm Transplantation; Pyrroles/chemistry; Pyrroles/pharmacology; Structure-Activity Relationship; Transplantation, Heterologous

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Database: MEDLINE Main subject: Pyrroles / Distamycins / Guanidines / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Year: 2004 Type: Article

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