A new oral anticoagulant: the 50-year challenge.

Gustafsson, David; Bylund, Ruth; Antonsson, Thomas; Nilsson, Ingemar; Nyström, Jan-Erik; Eriksson, Ulf; Bredberg, Ulf; Teger-Nilsson, Ann-Catrine

Gustafsson, David; Bylund, Ruth; Antonsson, Thomas; Nilsson, Ingemar; Nyström, Jan-Erik; Eriksson, Ulf; Bredberg, Ulf; Teger-Nilsson, Ann-Catrine.

Affiliation

Gustafsson D; AstraZeneca R&D Mölndal, S-431 83 Mölndal, Sweden. david.gustafsson@astrazeneca.com

Nat Rev Drug Discov ; 3(8): 649-59, 2004 Aug.

Article in En | MEDLINE | ID: mdl-15286732

Subject(s)

Anticoagulants; Azetidines; Blood Coagulation/physiology; Thrombosis/drug therapy; Administration, Oral; Animals; Anticoagulants/chemistry; Anticoagulants/pharmacokinetics; Anticoagulants/therapeutic use; Area Under Curve; Azetidines/chemistry; Azetidines/pharmacokinetics; Azetidines/therapeutic use; Benzylamines; Biological Availability; Humans; Intestinal Absorption; Prodrugs/chemistry; Prodrugs/metabolism; Prodrugs/therapeutic use; Structure-Activity Relationship

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Database: MEDLINE Main subject: Azetidines / Thrombosis / Blood Coagulation / Anticoagulants Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2004 Type: Article

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