In vitro and in vivo characterization of a novel naphthylamide ATP-sensitive K+ channel opener, A-151892.

Gopalakrishnan, Murali; Buckner, Steven A; Shieh, Char-Chang; Fey, Thomas; Fabiyi, Adebola; Whiteaker, Kristi L; Davis-Taber, Rachel; Milicic, Ivan; Daza, Anthony V; Scott, Victoria E S; Castle, Neil A; Printzenhoff, David; London, Brecht; Turner, Sean C; Carroll, William A; Sullivan, James P; Coghlan, Michael J; Brune, Michael E

Gopalakrishnan, Murali; Buckner, Steven A; Shieh, Char-Chang; Fey, Thomas; Fabiyi, Adebola; Whiteaker, Kristi L; Davis-Taber, Rachel; Milicic, Ivan; Daza, Anthony V; Scott, Victoria E S; Castle, Neil A; Printzenhoff, David; London, Brecht; Turner, Sean C; Carroll, William A; Sullivan, James P; Coghlan, Michael J; Brune, Michael E.

Affiliation

Gopalakrishnan M; Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA. mural.gopalakrishnan@abbott.com

Br J Pharmacol ; 143(1): 81-90, 2004 Sep.

Article in En | MEDLINE | ID: mdl-15302680

Subject(s)

Acetamides/pharmacology; Adenosine Triphosphate/physiology; Naphthalenes/pharmacology; Potassium Channels/agonists; Animals; Barbiturates/metabolism; Binding, Competitive/drug effects; Blood Pressure/drug effects; Blood Vessels/drug effects; Female; Guanidines/pharmacology; Guinea Pigs; In Vitro Techniques; Iodine Radioisotopes; Isoxazoles/metabolism; Membrane Potentials/drug effects; Muscle Relaxation/drug effects; Muscle, Smooth, Vascular/drug effects; Patch-Clamp Techniques; Pyridines/pharmacology; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Swine; Urinary Bladder/drug effects

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Full text: 1 Database: MEDLINE Main subject: Potassium Channels / Adenosine Triphosphate / Acetamides / Naphthalenes Type of study: Diagnostic_studies Limits: Animals Language: En Year: 2004 Type: Article

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