Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells.

Barata, Joao T; Silva, Ana; Brandao, Joana G; Nadler, Lee M; Cardoso, Angelo A; Boussiotis, Vassiliki A

Barata, Joao T; Silva, Ana; Brandao, Joana G; Nadler, Lee M; Cardoso, Angelo A; Boussiotis, Vassiliki A.

Affiliation

Barata JT; Tumor Biology Unit, Institute of Molecular Medicine, University of Lisbon Medical School, 1649-028, Lisbon, Portugal.

J Exp Med ; 200(5): 659-69, 2004 Sep 06.

Article in En | MEDLINE | ID: mdl-15353558

Subject(s)

Glucose/metabolism; Interleukin-7/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism; T-Lymphocytes/metabolism; Antigens, CD/biosynthesis; Antigens, Differentiation, B-Lymphocyte/biosynthesis; Antigens, Differentiation, T-Lymphocyte/biosynthesis; Cell Cycle; Cell Cycle Proteins/metabolism; Cell Division; Cell Survival; Cyclin-Dependent Kinase Inhibitor p27; Down-Regulation; Enzyme Inhibitors/pharmacology; Flavonoids/pharmacology; Glucose Transporter Type 1; Humans; Immunoblotting; Immunophenotyping; Lectins, C-Type; Membrane Potentials; Mitochondria/pathology; Mitogen-Activated Protein Kinase Kinases/metabolism; Mitogen-Activated Protein Kinases/metabolism; Monosaccharide Transport Proteins/metabolism; Phosphorylation; Precipitin Tests; Receptors, Transferrin; Signal Transduction; Time Factors; Tumor Suppressor Proteins/metabolism; Up-Regulation

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Full text: 1 Database: MEDLINE Main subject: T-Lymphocytes / Interleukin-7 / Phosphatidylinositol 3-Kinases / Precursor Cell Lymphoblastic Leukemia-Lymphoma / Glucose Limits: Humans Language: En Year: 2004 Type: Article

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