Long-term changes in rabbit cornea after ionizing radiation.
Cornea
; 23(8 Suppl): S87-90, 2004 Nov.
Article
in En
| MEDLINE
| ID: mdl-15448487
ABSTRACT
PURPOSE:
To investigate long-term changes in the cornea after ionizing irradiation in rabbits.METHODS:
Mature albino rabbits (n = 4) were unilaterally irradiated with 20 Gy of x-rays. The contralateral eye served as a control. The rabbits were examined with slit-lamp biomicroscopy for 5 years. The eyes were then enucleated for histopathologic examinations with light microscopy and transmission electron microscopy.RESULTS:
On biomicroscopy, there was no corneal abnormality during the 5-year follow-up period. On histopathology, no abnormality was observed in the corneal epithelium. In the endothelium, a vacuole-like structure was recognized by light microscopy, and transmission electron microscopy revealed marked enlargement of intercellular space and anamorphosis of the nuclei.CONCLUSION:
Moderate x-ray irradiation to rabbit eye did not induce any long-term damage to the corneal epithelium, but the endothelium demonstrated persistent and irreversible damage, which was observed even 5 years after irradiation.
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Database:
MEDLINE
Main subject:
Radiation Injuries, Experimental
/
Endothelium, Corneal
/
Epithelium, Corneal
/
Cornea
Limits:
Animals
Language:
En
Year:
2004
Type:
Article