Mechanism-based inactivation of CYP3A by HIV protease inhibitors.

Ernest, C Steven; Hall, Stephen D; Jones, David R

Ernest, C Steven; Hall, Stephen D; Jones, David R.

Affiliation

Ernest CS; Division of Clinical Pharmacology, Wishard Memorial Hospital, 1001 W. 10th St., WD Myers Bldg., W7123, Indianapolis, IN 46202, USA.

J Pharmacol Exp Ther ; 312(2): 583-91, 2005 Feb.

Article in En | MEDLINE | ID: mdl-15523003

Subject(s)

Aryl Hydrocarbon Hydroxylases/antagonists & inhibitors; Enzyme Inhibitors; HIV Protease Inhibitors/pharmacology; Oxidoreductases, N-Demethylating/antagonists & inhibitors; Aldehydes/chemistry; Algorithms; Cytochrome P-450 CYP3A; DNA, Complementary/biosynthesis; DNA, Complementary/genetics; Humans; Iron/chemistry; Kinetics; Microbial Sensitivity Tests; Microsomes, Liver/drug effects; Microsomes, Liver/enzymology; Reactive Oxygen Species; Spectrophotometry, Ultraviolet

Search on Google

XML

PubMed Links

Database: MEDLINE Main subject: Oxidoreductases, N-Demethylating / Aryl Hydrocarbon Hydroxylases / HIV Protease Inhibitors / Enzyme Inhibitors Limits: Humans Language: En Year: 2005 Type: Article

Search on Google

XML

PubMed Links