Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase.

Thoma, Ralf; Schulz-Gasch, Tanja; D'Arcy, Brigitte; Benz, Jörg; Aebi, Johannes; Dehmlow, Henrietta; Hennig, Michael; Stihle, Martine; Ruf, Armin

Thoma, Ralf; Schulz-Gasch, Tanja; D'Arcy, Brigitte; Benz, Jörg; Aebi, Johannes; Dehmlow, Henrietta; Hennig, Michael; Stihle, Martine; Ruf, Armin.

Affiliation

Thoma R; F. Hoffmann-La Roche AG, Pharma Research Discovery Chemistry, 4070 Basel, Switzerland.

Nature ; 432(7013): 118-22, 2004 Nov 04.

Article in En | MEDLINE | ID: mdl-15525992

Subject(s)

Intramolecular Transferases/chemistry; Intramolecular Transferases/metabolism; Lanosterol/metabolism; Squalene/analogs & derivatives; Anticholesteremic Agents/chemistry; Anticholesteremic Agents/pharmacology; Benzophenones/chemistry; Benzophenones/pharmacology; Catalysis; Crystallography, X-Ray; Cyclization; Drug Design; Humans; Intramolecular Transferases/antagonists & inhibitors; Lanosterol/chemistry; Models, Molecular; Squalene/metabolism; Structure-Activity Relationship

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PubMed Links

Database: MEDLINE Main subject: Squalene / Intramolecular Transferases / Lanosterol Limits: Humans Language: En Year: 2004 Type: Article

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PubMed Links

Database: MEDLINE Main subject: Squalene / Intramolecular Transferases / Lanosterol Limits: Humans Language: En Year: 2004 Type: Article