Gradually glycosylated protein C mutants (Arg178Gln and Cys331Arg) are degraded by proteasome after mannose trimming.

Nakahara, Masako; Koyama, Takatoshi; Nakazawa, Fumie; Nishio, Miwako; Shibamiya, Aya; Hirosawa, Shinsaku

Nakahara, Masako; Koyama, Takatoshi; Nakazawa, Fumie; Nishio, Miwako; Shibamiya, Aya; Hirosawa, Shinsaku.

Affiliation

Nakahara M; Laboratory Molecular Genetics, Graduate School of Health Sciences, Tokyo, Japan.

Thromb Haemost ; 92(6): 1284-90, 2004 Dec.

Article in En | MEDLINE | ID: mdl-15583735

Subject(s)

Endoplasmic Reticulum/metabolism; Mannose/chemistry; Proteasome Endopeptidase Complex/metabolism; Protein C/genetics; Animals; Arginine/chemistry; Asparagine/chemistry; Binding Sites; CHO Cells; Cricetinae; Cysteine/chemistry; DNA, Complementary/metabolism; Dose-Response Relationship, Drug; Genetic Vectors; Glucose/metabolism; Glutamine/chemistry; Glycosylation; Immunoprecipitation; Mutation; Oligosaccharides/chemistry; Proteasome Inhibitors; Recombinant Proteins/chemistry; Time Factors; Transfection

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Database: MEDLINE Main subject: Protein C / Proteasome Endopeptidase Complex / Endoplasmic Reticulum / Mannose Limits: Animals Language: En Year: 2004 Type: Article

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PubMed Links

Database: MEDLINE Main subject: Protein C / Proteasome Endopeptidase Complex / Endoplasmic Reticulum / Mannose Limits: Animals Language: En Year: 2004 Type: Article