Neuroprotective effect of the immune system in a mouse model of severe dysmyelinating hereditary neuropathy: enhanced axonal degeneration following disruption of the RAG-1 gene.

Berghoff, Martin; Samsam, Mohtashem; Müller, Marcus; Kobsar, Igor; Toyka, Klaus V; Kiefer, Reinhard; Mäurer, Mathias; Martini, Rudolf

Berghoff, Martin; Samsam, Mohtashem; Müller, Marcus; Kobsar, Igor; Toyka, Klaus V; Kiefer, Reinhard; Mäurer, Mathias; Martini, Rudolf.

Affiliation

Berghoff M; Section of Developmental Neurobiology, Department of Neurology, University of Würzburg, 97080 Würzburg, Germany.

Mol Cell Neurosci ; 28(1): 118-27, 2005 Jan.

Article in En | MEDLINE | ID: mdl-15607947

Subject(s)

Demyelinating Diseases/immunology; Genes, RAG-1/genetics; Immune System/immunology; Peripheral Nervous System Diseases/immunology; Wallerian Degeneration/immunology; Age Factors; Animals; CD8-Positive T-Lymphocytes/immunology; Cell Proliferation; Cell Survival/genetics; Cell Survival/immunology; Chemotaxis, Leukocyte/genetics; Chemotaxis, Leukocyte/immunology; Demyelinating Diseases/genetics; Demyelinating Diseases/physiopathology; Disease Models, Animal; Macrophages/immunology; Mice; Mice, Knockout; Microscopy, Electron, Transmission; Myelin P0 Protein/deficiency; Myelin P0 Protein/genetics; Peripheral Nerves/metabolism; Peripheral Nerves/pathology; Peripheral Nerves/ultrastructure; Peripheral Nervous System Diseases/genetics; Peripheral Nervous System Diseases/physiopathology; Tibial Nerve/metabolism; Tibial Nerve/pathology; Tibial Nerve/ultrastructure; Wallerian Degeneration/genetics; Wallerian Degeneration/physiopathology

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Database: MEDLINE Main subject: Wallerian Degeneration / Demyelinating Diseases / Genes, RAG-1 / Peripheral Nervous System Diseases / Immune System Type of study: Prognostic_studies Limits: Animals Language: En Year: 2005 Type: Article

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