Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression.

Rothstein, Jeffrey D; Patel, Sarjubhai; Regan, Melissa R; Haenggeli, Christine; Huang, Yanhua H; Bergles, Dwight E; Jin, Lin; Dykes Hoberg, Margaret; Vidensky, Svetlana; Chung, Dorothy S; Toan, Shuy Vang; Bruijn, Lucie I; Su, Zao-Zhong; Gupta, Pankaj; Fisher, Paul B

Rothstein, Jeffrey D; Patel, Sarjubhai; Regan, Melissa R; Haenggeli, Christine; Huang, Yanhua H; Bergles, Dwight E; Jin, Lin; Dykes Hoberg, Margaret; Vidensky, Svetlana; Chung, Dorothy S; Toan, Shuy Vang; Bruijn, Lucie I; Su, Zao-Zhong; Gupta, Pankaj; Fisher, Paul B.

Affiliation

Rothstein JD; Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21287, USA. jrothste@jhmi.edu

Nature ; 433(7021): 73-7, 2005 Jan 06.

Article in En | MEDLINE | ID: mdl-15635412

Subject(s)

Anti-Bacterial Agents/pharmacology; Excitatory Amino Acid Transporter 2/biosynthesis; Excitatory Amino Acid Transporter 2/genetics; Gene Expression Regulation/drug effects; Neuroprotective Agents/pharmacology; beta-Lactams/pharmacology; Animals; Ceftriaxone/pharmacology; Cell Count; Cells, Cultured; Central Nervous System/cytology; Central Nervous System/drug effects; Drug Evaluation, Preclinical; Genes, Reporter/genetics; In Vitro Techniques; Ischemic Preconditioning; Mice; Mice, Transgenic; Motor Neurons/cytology; Motor Neurons/drug effects; Penicillins/pharmacology; Promoter Regions, Genetic/genetics; RNA, Messenger/genetics; RNA, Messenger/metabolism; Transcriptional Activation; United States; United States Food and Drug Administration

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Database: MEDLINE Main subject: Gene Expression Regulation / Neuroprotective Agents / Excitatory Amino Acid Transporter 2 / Beta-Lactams / Anti-Bacterial Agents Limits: Animals Country/Region as subject: America do norte Language: En Year: 2005 Type: Article

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