Effects of blocking urokinase receptor signaling by antisense oligonucleotides in a mouse model of experimental prostate cancer bone metastases.

Margheri, F; D'Alessio, S; Serratí, S; Pucci, M; Annunziato, F; Cosmi, L; Liotta, F; Angeli, R; Angelucci, A; Gravina, G L; Rucci, N; Bologna, M; Teti, A; Monia, B; Fibbi, G; Del Rosso, M

Margheri, F; D'Alessio, S; Serratí, S; Pucci, M; Annunziato, F; Cosmi, L; Liotta, F; Angeli, R; Angelucci, A; Gravina, G L; Rucci, N; Bologna, M; Teti, A; Monia, B; Fibbi, G; Del Rosso, M.

Affiliation

Margheri F; Department of Experimental Pathology and Oncology, University of Florence, Italy.

Gene Ther ; 12(8): 702-14, 2005 Apr.

Article in En | MEDLINE | ID: mdl-15674398

Subject(s)

Bone Neoplasms/secondary; Bone Neoplasms/therapy; Genetic Therapy/methods; Oligonucleotides, Antisense/administration & dosage; Prostatic Neoplasms/therapy; Receptors, Cell Surface/genetics; Animals; Bone Neoplasms/metabolism; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Cyclin A/analysis; Cyclin A/metabolism; Cyclin B/analysis; Cyclin B/metabolism; Cyclin B1; Cyclin D1/analysis; Cyclin D1/metabolism; Cyclin D3; Cyclins/analysis; Cyclins/metabolism; Extracellular Matrix/metabolism; Humans; Injections; Male; Mice; Mice, Nude; Neoplasm Transplantation; Prostatic Neoplasms/metabolism; Receptors, Cell Surface/metabolism; Receptors, Urokinase Plasminogen Activator; Signal Transduction

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Database: MEDLINE Main subject: Prostatic Neoplasms / Bone Neoplasms / Genetic Therapy / Oligonucleotides, Antisense / Receptors, Cell Surface Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Year: 2005 Type: Article

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