Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival.

Carón, Rubén W; Yacoub, Adly; Li, Min; Zhu, Xiaoyu; Mitchell, Clint; Hong, Young; Hawkins, William; Sasazuki, Takehiko; Shirasawa, Senji; Kozikowski, Alan P; Dennis, Philip A; Hagan, Michael P; Grant, Steven; Dent, Paul

Carón, Rubén W; Yacoub, Adly; Li, Min; Zhu, Xiaoyu; Mitchell, Clint; Hong, Young; Hawkins, William; Sasazuki, Takehiko; Shirasawa, Senji; Kozikowski, Alan P; Dennis, Philip A; Hagan, Michael P; Grant, Steven; Dent, Paul.

Affiliation

Carón RW; Department of Radiation Oncology, Medical College of Virginia, Virginia Commonwealth University, 401 College Street, Richmond, VA 23298-0058, USA.

Mol Cancer Ther ; 4(2): 257-70, 2005 Feb.

Article in En | MEDLINE | ID: mdl-15713897

Subject(s)

Carcinoma/enzymology; Cell Membrane/enzymology; Colonic Neoplasms/enzymology; Enzyme Inhibitors/pharmacology; Phosphotransferases (Alcohol Group Acceptor)/antagonists & inhibitors; Radiation Tolerance/physiology; ras Proteins/physiology; 3-Phosphoinositide-Dependent Protein Kinases; Carcinoma/genetics; Cell Membrane/chemistry; Cell Survival/drug effects; Colonic Neoplasms/genetics; Enzyme Activation/radiation effects; Gene Deletion; Humans; Mutation/genetics; Phosphatidylinositol 3-Kinases/analysis; Phosphatidylinositol 3-Kinases/metabolism; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor)/analysis; Phosphotransferases (Alcohol Group Acceptor)/metabolism; Protein Serine-Threonine Kinases/analysis; Protein Serine-Threonine Kinases/antagonists & inhibitors; Protein Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins/analysis; Proto-Oncogene Proteins/antagonists & inhibitors; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-akt; RNA, Small Interfering/genetics; RNA, Small Interfering/pharmacology; Signal Transduction; Tumor Cells, Cultured; ras Proteins/genetics; ras Proteins/metabolism

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Database: MEDLINE Main subject: Radiation Tolerance / Carcinoma / Cell Membrane / Phosphotransferases (Alcohol Group Acceptor) / Colonic Neoplasms / Ras Proteins / Enzyme Inhibitors Type of study: Risk_factors_studies Limits: Humans Language: En Year: 2005 Type: Article

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