Antitumor activity of orally bioavailable farnesyltransferase inhibitor, ABT-100, is mediated by antiproliferative, proapoptotic, and antiangiogenic effects in xenograft models.

Ferguson, Debra; Rodriguez, Luis E; Palma, Joann P; Refici, Marion; Jarvis, Kenneth; O'Connor, Jacqueline; Sullivan, Gerard M; Frost, David; Marsh, Kennan; Bauch, Joy; Zhang, Haiying; Lin, Nan-Horng; Rosenberg, Saul; Sham, Hing L; Joseph, Ingrid B J K

Ferguson, Debra; Rodriguez, Luis E; Palma, Joann P; Refici, Marion; Jarvis, Kenneth; O'Connor, Jacqueline; Sullivan, Gerard M; Frost, David; Marsh, Kennan; Bauch, Joy; Zhang, Haiying; Lin, Nan-Horng; Rosenberg, Saul; Sham, Hing L; Joseph, Ingrid B J K.

Affiliation

Ferguson D; Abbott Laboratories, Abbott Park, Illinois 60064, USA.

Clin Cancer Res ; 11(8): 3045-54, 2005 Apr 15.

Article in En | MEDLINE | ID: mdl-15837760

Subject(s)

Alkyl and Aryl Transferases/antagonists & inhibitors; Angiogenesis Inhibitors/pharmacology; Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Imidazoles/pharmacology; Xenograft Model Antitumor Assays/methods; Administration, Oral; Angiogenesis Inhibitors/pharmacokinetics; Animals; Antineoplastic Agents/blood; Antineoplastic Agents/pharmacokinetics; Area Under Curve; Biological Availability; Cell Line, Tumor; Cell Proliferation/drug effects; Dose-Response Relationship, Drug; Enzyme Inhibitors/pharmacokinetics; Enzyme Inhibitors/pharmacology; Farnesyltranstransferase; Fibroblast Growth Factor 2/metabolism; Humans; Imidazoles/blood; Imidazoles/pharmacokinetics; Interleukin-8/metabolism; Male; Mice; Mice, Nude; Mice, SCID; Neovascularization, Pathologic/metabolism; Neovascularization, Pathologic/pathology; Neovascularization, Pathologic/prevention & control; Vascular Endothelial Growth Factor A/metabolism

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Database: MEDLINE Main subject: Apoptosis / Alkyl and Aryl Transferases / Angiogenesis Inhibitors / Xenograft Model Antitumor Assays / Imidazoles / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Year: 2005 Type: Article

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