Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension.
Nat Struct Mol Biol
; 12(6): 554-5, 2005 Jun.
Article
in En
| MEDLINE
| ID: mdl-15908963
ABSTRACT
The S810L mutation within the human mineralocorticoid receptor (MR S810L) induces severe hypertension and switches progesterone from antagonist to agonist. Here we report the crystal structures of the ligand-binding domain of MR S810L in complex with progesterone and deoxycorticosterone, an agonist of both wild-type and mutant MRs. These structures, the first for MR, identify the specific contacts created by Leu810 and clarify the mechanism of activation of MR S810L.
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Database:
MEDLINE
Main subject:
Receptors, Mineralocorticoid
/
Hypertension
Limits:
Humans
Language:
En
Year:
2005
Type:
Article