[Placental expression of human histocompatibility antigen-G mRNA in idiopathic fetal growth restriction and its relationship with pathological changes of placenta].
Zhonghua Fu Chan Ke Za Zhi
; 40(4): 249-52, 2005 Apr.
Article
in Zh
| MEDLINE
| ID: mdl-15924672
ABSTRACT
OBJECTIVE:
To investigate the expressions of human histocompatibility antigen-G (HLA-G) mRNA in placenta of idiopathic fetal growth restriction (IFGR) and its relationship with pathogenesis of IFGR.METHODS:
In situ hybridization was used to investigate the expression level and distribution of HLA-G mRNA in placentas of 20 cases of idiopathic IFGR and 28 cases of control group. HE stain was applied to observe the pathological changes of the placenta.RESULTS:
(1) The incidence of placental pathological lesions in idiopathic IFGR (75%) was notably higher than those of the control group (18%), (chi2 = 15.67, P = 0.001). (2) In situ hybridization showed the positive expression rate of HLA-G mRNA in placenta of idiopathic IFGR was 45%, that of control group was 79%, with significant difference between the two groups (chi2 = 5.75, P = 0.017). HLA-G mRNA signal mainly expressed in cytotrophoblast and syncytiotrophoblast. (3) There was negative correlation between the expression rate of HLA-G mRNA and incidence of placental pathological lesions (r = -0.638, P = 0.008).CONCLUSIONS:
There is a significant decrease in the expression of HLA-G mRNA in IFGR. HLA-G may play a role in the pathogenesis of IFGR.
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Database:
MEDLINE
Main subject:
Placenta
/
Histocompatibility Antigens Class I
/
Gene Expression Regulation
/
Fetal Growth Retardation
/
HLA Antigens
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Newborn
/
Pregnancy
Language:
Zh
Year:
2005
Type:
Article