Design and synthesis of protein superfamily-targeted chemical libraries for lead identification and optimization.

Shuttleworth, Stephen J; Connors, Richard V; Fu, Jiasheng; Liu, Jinqian; Lizarzaburu, Mike E; Qiu, Wei; Sharma, Rajiv; Wãnska, Malgorzata; Zhang, Alex J

Shuttleworth, Stephen J; Connors, Richard V; Fu, Jiasheng; Liu, Jinqian; Lizarzaburu, Mike E; Qiu, Wei; Sharma, Rajiv; Wãnska, Malgorzata; Zhang, Alex J.

Affiliation

Shuttleworth SJ; Department of Chemistry, Tularik Inc., 1120 Veterans Boulevard, South San Francisco, CA 94404, USA. Stephen.Shuttleworth@piramed.com

Curr Med Chem ; 12(11): 1239-81, 2005.

Article in En | MEDLINE | ID: mdl-15974996

Subject(s)

Drug Design; Drug Evaluation, Preclinical/methods; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/pharmacology; Protein Kinases/metabolism; Receptors, Cytoplasmic and Nuclear/metabolism; Receptors, G-Protein-Coupled/metabolism; Enzyme Inhibitors/chemistry; Humans; Receptors, Cytoplasmic and Nuclear/antagonists & inhibitors; Receptors, G-Protein-Coupled/antagonists & inhibitors

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Database: MEDLINE Main subject: Protein Kinases / Drug Design / Receptors, Cytoplasmic and Nuclear / Receptors, G-Protein-Coupled / Drug Evaluation, Preclinical / Enzyme Inhibitors Type of study: Diagnostic_studies Limits: Humans Language: En Year: 2005 Type: Article

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