Non protein bound iron concentrations in amniotic fluid.
Clin Biochem
; 38(7): 674-7, 2005 Jul.
Article
in En
| MEDLINE
| ID: mdl-16009144
ABSTRACT
OBJECTIVES:
To investigate whether amniotic fluid concentrations of non protein bound iron (NPBI) vary with growth in healthy fetuses and also offer a reference curve in the second trimester of pregnancy. DESIGN ANDMETHODS:
Amniotic fluid concentrations of NPBI were measured by HPLC in 118 women with physiological singleton pregnancies, who underwent amniocentesis for fetal karyotype between weeks 15 and 18 of gestation.RESULTS:
NPBI increased progressively from weeks 14--15 to weeks 15--16, peaking at 17--18 weeks of gestation. NPBI values regressed positively with gestational age (GA). Multiple linear regression analysis between NPBI, as dependent variable, and various fetal parameters, as independent variables, showed a statistically significant regression coefficient with GA, bi-parietal diameter and transverse cerebellar diameter.CONCLUSIONS:
The present data constitutes the first quantification of NPBI concentrations in amniotic fluid under physiological conditions. Correlations with GA and ultrasound fetal biometry suggest that NPBI may play a role in fetal growth.
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Database:
MEDLINE
Main subject:
Amniotic Fluid
/
Iron
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
En
Year:
2005
Type:
Article