Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation.

Poole, Kenneth E S; van Bezooijen, Rutger L; Loveridge, Nigel; Hamersma, Herman; Papapoulos, Socrates E; Löwik, Clemens W; Reeve, Jonathan

Poole, Kenneth E S; van Bezooijen, Rutger L; Loveridge, Nigel; Hamersma, Herman; Papapoulos, Socrates E; Löwik, Clemens W; Reeve, Jonathan.

Affiliation

Poole KE; MRC Bone Research Group, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. kesp2@cam.ac.uk

FASEB J ; 19(13): 1842-4, 2005 Nov.

Article in En | MEDLINE | ID: mdl-16123173

Subject(s)

Bone Diseases, Developmental/metabolism; Bone Morphogenetic Proteins/physiology; Bone and Bones/metabolism; Genetic Markers/physiology; Osteocytes/metabolism; Adaptor Proteins, Signal Transducing; Aged; Alkaline Phosphatase/metabolism; Antibodies, Monoclonal/chemistry; Biopsy; Bone Development; Bone Diseases, Developmental/pathology; Bone Morphogenetic Proteins/chemistry; Bone Remodeling; Bone Resorption; Cell Differentiation; Coloring Agents/pharmacology; Female; Humans; Image Processing, Computer-Assisted; Immunohistochemistry; Male; Microscopy, Fluorescence; Middle Aged; Models, Biological; Osteoblasts/cytology; Osteocytes/cytology; Osteogenesis; RNA, Messenger/metabolism; Signal Transduction; Time Factors; Tolonium Chloride/pharmacology

Search on Google

XML

PubMed Links

Database: MEDLINE Main subject: Osteocytes / Bone and Bones / Bone Diseases, Developmental / Genetic Markers / Bone Morphogenetic Proteins Type of study: Prognostic_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Year: 2005 Type: Article

Search on Google

XML

PubMed Links